CJC-1295 no DAC
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Features & Compatibility
What is Peptide cjc 1295 (No DAC)?
Peptide cjc 1295 (No DAC) is a synthetic peptide analogue of growth hormone-releasing hormone (GHRH) designed to stimulate the pituitary gland to release growth hormone (GH). Unlike Peptide cjc 1295 with DAC (Drug Affinity Complex), the “No DAC” version lacks the stabilising modification, resulting in a shorter half-life but providing a pulsatile release of GH that mimics natural physiological secretion.
This property makes it particularly useful in research studies examining natural GH pulsatility, metabolic functions, and regenerative processes.
Summary Table
| Attribute | Details |
|---|---|
| Product Name | Peptide cjc 1295 (No DAC) |
| Classification | Synthetic Growth Hormone Releasing Hormone (GHRH) analog |
| Molecular Formula | C152H252N44O42 |
| Molecular Weight | ~3357.9 g/mol |
| CAS Number | 863288-34-0 |
| Sequence | Modified GHRH (1-29) fragment |
| Half-life | ~30 minutes (without DAC) |
| Storage | -20°C (lyophilized), reconstitute in bacteriostatic water |
Mechanism of Action | Peptide cjc 1295
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Peptide cjc 1295 (No DAC) binds to the GHRH receptor on pituitary somatotrophs.
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This binding triggers adenylate cyclase activation, increasing cAMP levels.
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Elevated cAMP stimulates growth hormone synthesis and release.
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Unlike the DAC-modified version (long-acting), CJC-1295 (No DAC) promotes short-term GH pulses similar to endogenous secretion patterns.
Key Point: This distinction makes it highly relevant for research models focusing on short-term GH effects, circadian regulation, and tissue repair mechanisms.
Research Applications
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Growth Hormone Secretion Studies
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Analysis of pulsatile vs. sustained GH release.
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Comparative studies with DAC-modified peptides.
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Metabolic Research
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Insulin sensitivity and glucose metabolism.
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Lipolysis and fat oxidation pathways.
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Musculoskeletal Studies
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Effects on muscle repair and recovery.
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Bone density and connective tissue regeneration.
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Neuroprotective & Cognitive Function Research
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Investigating the GH/IGF-1 axis in memory and neuroplasticity.
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Anti-Aging & Cellular Repair Studies
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Role in mitochondrial health.
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Collagen synthesis and skin physiology research.
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Safety & Tolerability
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Common Research Observations:
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Mild flushing
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Temporary injection site reactions
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Short-lived fatigue
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Comparison with Peptide cjc 1295 DAC:
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No DAC = shorter half-life, reduced systemic accumulation.
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Considered safer in studies requiring controlled, acute GH release.
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⚠️ Disclaimer: This compound is intended strictly for research purposes. It is not approved for human consumption or therapeutic use.
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