IGF-1 LR3
IGF-1 LR3 – 100 mcg, Reagent Grade
Premium-quality IGF-1 LR3 (100 mcg) designed for advanced research applications. Extensively studied for its potential role in cellular growth, regeneration, and metabolic pathways. Supplied in lyophilised form for stability and consistency. For laboratory research use only.
Original price was: $26.00.$20.00Current price is: $20.00.
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Features & Compatibility
What is IGF-1 LR3? Igf 1 for sale
Igf 1 for Sale LR3 (Insulin-Like Growth Factor-1 Long Arg3) is a recombinant peptide analogue of human IGF-1, engineered to have a longer half-life and enhanced biological activity. By replacing the third amino acid with arginine (Arg3) and extending its structure, IGF-1 LR3 resists binding to IGF-binding proteins (IGFBPs), increasing its bioavailability. Researchers utilise IGF-1 LR3 for studies in cellular growth, tissue repair, muscle development, and metabolic signalling.
Product Summary – IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1)
| Field | Details |
| Product Name | Igf 1 for Sale LR3 (Long Arg³ Insulin-like Growth Factor-1). |
| Category | Synthetic recombinant IGF-1 analogue; modified to improve stability and bioavailability. |
| Length | 83 amino acids (13 amino acids longer than native IGF-1). |
| Amino Acid Sequence | Modified IGF-1 sequence with a 13-amino acid N-terminal extension and substitution of Arg for Glu at position 3. |
| Molecular Formula & Weight | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉; molecular weight ≈ 9,111 Da. |
| Form & Purity | Lyophilised peptide powder; typical research purity ≥95% (HPLC). |
| Storage | Store dry at −20°C; protect from light and moisture. Reconstituted solutions should be refrigerated (2–8°C) and used within days. |
| Key Mechanisms of Action | • Potent agonist at the IGF-1 receptor → stimulates PI3K/Akt and MAPK pathways.
• Promotes protein synthesis, cell survival, and proliferation. • Enhances glucose uptake and insulin-like metabolic effects. • Longer half-life (~20–30 h vs ~12 min native IGF-1) due to reduced binding to IGF binding proteins (IGFBPs). |
| Research / Clinical Use Cases | • Studied muscle growth and regeneration models (satellite cell activation, myoblast proliferation).
• Neuroprotective and cognitive function research (supports neuronal survival and plasticity). • Investigated in metabolic studies for insulin sensitivity and glucose control. • Wound healing and tissue repair models. |
| Common AEs / Safety Signals | Possible hypoglycaemia (insulin-like effect), oedema, arthralgia, and headache. Risk rises with supraphysiologic dosing. |
| Contraindications / Warnings | Not FDA-approved. Caution in malignancy due to proliferative/anti-apoptotic properties. Research use only. |
| Regulatory / Compliance | Not approved for therapeutic use in major jurisdictions. Prohibited in competitive sports under WADA. |
Chemical Structure
Igf 1 for Sale LR3 is a single-chain polypeptide of 83 amino acids. Its modifications (Arg3 substitution and an extended N-terminus) reduce binding to IGFBPs and prolong systemic activity.
Mechanism of Action
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IGF-1 Receptor Activation – Igf 1 for Sale LR3 binds to the IGF-1 receptor (IGF-1R), triggering tyrosine kinase signalling.
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PI3K/AKT & MAPK Pathways – Activates intracellular pathways involved in protein synthesis, cell survival, and proliferation.
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Reduced IGFBP Affinity – Structural modifications prevent sequestration by IGFBPs, increasing free peptide availability.
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Metabolic Regulation – Enhances glucose uptake, insulin sensitivity, and lipid metabolism.
Research Applications | Igf 1 for sale
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Muscle Biology – Studied for hypertrophy, myoblast proliferation, and satellite cell activation.
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Neuroprotection – Investigated for its role in neuronal survival and repair mechanisms.
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Tissue Regeneration – Applied in studies of wound healing, cartilage repair, and angiogenesis.
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Endocrinology & Metabolism – Used to explore insulin-like effects, glucose regulation, and metabolic pathways.
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Oncology Research – Examined for its influence on tumour progression and resistance mechanisms due to growth factor signalling.
Safety & Tolerability
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Preclinical Findings: Igf 1 for Sale LR3 demonstrates potent biological activity but requires strict dosing in experimental settings.
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Adverse Effects: High levels may induce hypoglycaemia, oedema, or abnormal tissue growth in research models.
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Research Use Only: Not approved for human or veterinary therapeutic use. Handling requires biosafety protocols in compliance with laboratory standards
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